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Clomid, Nolvadex and stimulate the production of testosterone

Recently, I received a large number of angry comments about my preferences Nolvadex over Clomid, which I use in all cases (at least in the field of bodybuilding); as an antiestrogen as drug supports good cholesterol and testosterone stimulant. In any case, most people use Nolvadex instead of Clomid for combating ginekomestiey. As for cholesterol, most people do not pay attention to this important issue. But when it comes to using Nolvadex for raising the endogenous production of testosterone, most bodybuilders do not want to hear about it. They apparently only want Clomid. I can only guess that it is based on a profound misunderstanding of the effect of these drugs. In this way,

Kłomino and Nolvadex

I do not know why Clomid and Nolvadex became so different in the minds of bodybuilders. Definitely they are not solely responsible to be. Clomid and Nolvadex is an antiestrogen trifeniletilenov belonging to the same group. They are structurally similar and are classified as selective estrogen receptor modulators with mixed agonistic and antagonistic properties. This means that in certain tissues they block the action of estrogen by binding to receptors, whereas in other tissues can act as a real estrogen by activating receptors. In males, both drugs act as antiestrogens in its ability to interfere with the estrogen negative feedback on the hypothalamus and stimulate increased production of GnRH (GnRH). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only good for Clomid testosterone stimulation. In this article you will find some research that Nolvadex can not only be used for the same purposes, but in fact should be the preferred drug of the two.

Studies in the late 70’s in University of Ghent Belgium clarify advantages over Clomid Nolvadex in raising testosterone levels (1). Researchers looked at the effect of Nolvadex and Clomid on the endocrine system of healthy men, as well as those who have suffered from low sperm count (oligospermia). For our purposes it is obviously most interested in the effects of these drugs on healthy men. At the beginning of the study is quite instructive results were found. Nolvadex when used within 10 days at a dosage of 20 mg per day increased the level of testosterone in the serum of 142% of the initial level that was comparable with the effect of 150mg of Clomid per day for the same period of time (increase testosterone levels were slightly, but not significantly more Clomid). We must remember, that is the effect of three 50mg tablet of Clomid. At about the same price 50mg Clomid and 20mg Nolvadex we can already see a difference in the price / result in favor of Nolvadex.

The sensitivity of the pituitary to GnRH.

But there is something more interesting. The researchers also carried out tests on the stimulation of GnRH before and after treatment with Nolvadex and Clomid and these two drugs showed significantly different results. These tests included the introduction patsientav 100mcg GnRH and measuring production of luteinizing hormone by the pituitary gland in response. The purpose of this test was to see how sensitive the pituitary to GnRH. The more sensitive the pituitary, the more LH is produced. Tests have shown that after ten days of treatment with Nolvadex pituitary sensitivity to GnRH increased slightly compared with the state before the reception. This contrasts with the 10-day intake 150mg Clomid, which showed reduced sensitivity to the pituitary GnRH (luteinizing hormone is produced longer before receiving). As studies Nolvadex continued until 6 weeks, pituitary sensitivity to GnRH increased significantly compared with the state before sending or receiving a 10-day level. In this case, the same increase caused 20mg testosterone and luteinizing hormone in average by 183% and 172% of the initial values, respectively, which is significantly higher than it was at 10-day therapy. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. pituitary sensitivity to GnRH increased significantly compared with the state before sending or receiving a 10-day level. In this case, the same increase caused 20mg testosterone and luteinizing hormone in average by 183% and 172% of the initial values, respectively, which is significantly higher than it was at 10-day therapy. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. pituitary sensitivity to GnRH increased significantly compared with the state before sending or receiving a 10-day level. In this case, the same increase caused 20mg testosterone and luteinizing hormone in average by 183% and 172% of the initial values, respectively, which is significantly higher than it was at 10-day therapy. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. In this case, the same increase caused 20mg testosterone and luteinizing hormone in average by 183% and 172% of the initial values, respectively, which is significantly higher than it was at 10-day therapy. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. In this case, the same increase caused 20mg testosterone and luteinizing hormone in average by 183% and 172% of the initial values, respectively, which is significantly higher than it was at 10-day therapy. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex. while prolonged use of Nolvadex is only an increase in pituitary sensitivity to this hormone. We do not say that Clomid does not cause an increase in testosterone levels when taking over the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex.

Estrogen Clomid

The above-mentioned difference seems to be explained by differences in the estrogenic nature of the two drugs. The researchers clearly support this theory in the comments to their work: “The difference in results can be attributed to poor internal effects Clomid, which research has proved an increase in levels transcortin and testosterone / estradiol-binding globulin [SHBG]; this increase was not found after tamoxifen. ” In reviewing other theories later in the article, such as the effect of increased levels of androgen or estrogen, they continued to notice that the increase in these hormones were similar when using both drugs and concluded that “… the role of internal estrogenic activity of Clomid which is practically absent in Tamoxifen It seems the most likely explanation. ”

Although both are similar priparaty antiestrogens, they act very differently in different places. Apparently Nolvadex is a potent anti-estrogen in the hypothalamus and the pituitary gland, unlike Clomid, which although is a strong anti-estrogen in the hypothalamus, seems to exhibit weak estrogenic effect in the pituitary gland. To find a confirmation of this, we can look at the laboratory animal study, published by the American Journal of Physiology in February 1981 (2). This paper discusses the action of Clomid and Nolvadex GnRH due to the production of luteinizing hormone by cultured rat pituitary cells. In this paper it was shown that growing cells called Clomid direct estrogenic effect on the sensitivity of the cultured cells, causing weaker but still significant effect compared to estradiol. On the other hand Nolvadex has not had any noticeable effect on the production of luteinizing hormone. Moreover, he gently blocking the effects of estrogen when both were grown in the same culture.

Conclusion

Briefly summarizing the above studies, Nolvadex is more pure antiestrogen of the two drugs, at least if regarded axis hypothalamus-pituitary-testes. This fact gives an advantage over Nolvadex Clomid in male bodybuilders. This is especially true when we consider the rebalancing in the hypothalamic-pituitary-testes and do not want to reduce the sensitivity of the pituitary to GnRH. The presence of Clomid to raise LH to the same level may to some extent slow down the recovery, as the pituitary gland will need large quantities of GnRH from the hypothalamus.

Nolvadex is also preferable for long-term use, for those who find anti-estrogens effective enough at raising testosterone levels to use as anabolic steroids. In this case, Nolvadex would provide a better and more stable increase in testosterone levels and presumably would give similar or stronger than effeks Clomid for considerably less money. The potential increase in testosterone / estradiol binding globulin Clomid confirmed by another study (3) is also a concern, since this may lead to a relatively low level of active free testosterone compared with Nolvadex. Of course, both agents are effective antiestrogen to prevent gynecomastia and raise the level of endogenous testosterone,

The following month, in the continuation of this article, I will discuss the role of anti-estrogens in post-cycle testosterone recovery. More precisely, in detail and show you how to look right post-cycle therapy and explain why some anti-estrogens are not effective in this period of time.

ALPHA PHARMAClomid, Nolvadex and stimulate the production of testosterone